期刊
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
卷 36, 期 5, 页码 589-597出版社
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/H11-070
关键词
exercise; metabolism; muscle
Activation of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha)-mediated transcription is important for both the determination of mitochondrial content and the induction of mitochondrial biogenesis in skeletal muscle. SIRT1 (silent mating type information regulator 2 homolog 1) deactetylation is proposed as a potential activator of PGC-1 alpha transcriptional activity. The current review examines the importance of SIRT1 deacetylation of PGC-1 alpha in skeletal muscle. Models of SIRT1 overexpression and pharmacological activation are examined, but changes in SIRT1 expression and deacetylase activity following acute and chronic contractile activity will be emphasized. In addition, potential mechanisms of SIRT1 activation in skeletal muscle will be examined. The importance of the PGC-1 alpha acetyltransferase GCN5 will also be briefly discussed. The current evidence supports the contribution of SIRT1 deacetylation of PGC-1 alpha to exercise-induced mitochondrial biogenesis. Further research examining exercise-mediated activation of SIRT1 and the role of GCN5 in regulating PGC-1 alpha transcriptional activity in skeletal muscle is required.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据