期刊
JOURNAL OF CLINICAL IMMUNOLOGY
卷 24, 期 5, 页码 542-552出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JOCI.0000040925.55682.a5
关键词
EAE/MS; phytoestrogen; inflammation; cytokine signaling; T helper 1 cells; immunomodulation
类别
资金
- NCI NIH HHS [R21 CA106207-01] Funding Source: Medline
- NINDS NIH HHS [R01 NS42257-01A] Funding Source: Medline
Experimental allergic encephalomyelitis (EAE) is a Th1 cell-mediated inflammatory demyelinating autoimmune disease model of multiple sclerosis (MS). Quercetin (3,3'4', 5,7-pentahydroxy flavone) is a flavonoid phytoestrogen that has profound anticancer and anti-inflammatory activities. In this study, we show that in vivo treatment of SJL/J mice with quercetin (i.p. 50 or 100 mug every other day) ameliorates EAE in association with the inhibition of IL-12 production and neural antigen-specific Th1 differentiation. In vitro treatment of activated T cells with quercetin blocks IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4, resulting in a decrease in IL-12-induced T cell proliferation and Th1 differentiation. These findings highlight the fact that quercetin ameliorates EAE by blocking IL-12 signaling and Th1 differentiation and suggest its use in the treatment of MS and other Th1 cell-mediated autoimmune diseases.
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