期刊
NATURE REVIEWS CANCER
卷 4, 期 9, 页码 707-717出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1432
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Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify early cancer in high-risk people.
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