期刊
CLIMACTERIC
卷 7, 期 3, 页码 312-318出版社
PARTHENON PUBLISHING GROUP
DOI: 10.1080/13697130400003147
关键词
vaginal estrogens; menopausal symptoms; vaginal atrophy; urogenital atrophy; vaginal maturation index
Objective We investigated the effects of 2 months of treatment with topical estrogens on atrophic vaginitis and gynecological health in Asian women. Study design Multicenter, open-label trial of 150 postmenopausal women age < 70 years with atrophic vaginitis. Women applied conjugated equine estrogens (CEE) vaginal cream (0.625 mg/g) once daily on days 1-21 of two 28-day cycles. Changes in the vaginal maturation index (VMI) from baseline to days 21 (month 1) and 49 (month 2) were the primary outcome. Physiological changes were assessed by the Genital Health Clinical Examination (GHCE). Results The VMI was significantly improved (p < 0.001) from baseline at each assessment period. The significant improvement GHCE from baseline after month (p < 0.001) was maintained at 2 months. Conclusions Vaginal treatment with CEE cream for 21 days of two consecutive 28-day cycles resulted in beneficial changes in the vaginal tissues and induced an overall genital health pattern more characteristic of the premenopausal state.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据