期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 4, 期 9, 页码 1483-1492出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.4.9.1483
关键词
HIV-1 vaccine; parasitic infection
Vaccines are an economically efficient means of controlling viral infections, and it is likely that a vaccine against HIV-1 will be the most effective way of controlling the global AIDS crisis. However, an effective vaccine has not yet been attainable and in developing countries co-infection with protozoa and other chronic diseases adds another level of complexity to the design of an HIV-1 vaccine. Helminthic and protozoan infections can result in a constant state of immune activation that is characterised by a dominant T helper (Th)2 type of cytokine profile. Such an immune profile is likely to have an adverse impact on the efficacy of an HIV-1 vaccine CD8 cellular immune response and the corresponding Th1 cytokines that are most likely to be important for clearing viral infections.
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