All-native DNA transformation: a new approach to plant genetic engineering

Crop genetic engineering relies on the introduction of foreign DNA into plant genomes. Although genetically engineered traits provide valuable alternatives to those available through conventional breeding, there is public concern about the consumption of foods derived from transgenic plants. This concern raises the question of whether crops can be improved by inserting only native DNA into their genomes. Here, we discuss how rapid advances in molecular biology make it possible to use plants themselves as DNA sources. Native genes and regulatory elements can be reintroduced into plants without the need to use selectable markers. By also using transfer DNAs that are derived from within the targeted compatibility group, genetically engineered plants can now be produced that lack any foreign DNA.