期刊
INTERNATIONAL JOURNAL OF NEUROSCIENCE
卷 114, 期 9, 页码 1133-1145出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207450490475959
关键词
antioxidants; hippocampus; 3-NP; oxidative stress; taurine; vitamin Q vitamin E
The administration of 3-nitropropionic acid increases reactive oxygen species (ROS). Antioxidant defense mechanisms buffer these ROS converting them into non-damaging compounds. Taurine and vitamins C and E are antioxidants that play a role in the defense against cellular damage. This study examines the antioxidant effect of taurine, vitamin C, and vitamin E on acute hippocampal damage caused by 3-NP. Animals treated with 3-NP increased lipid peroxidation levels and astrocytic damage in the hippocampus. Administration of taurine, vitamin C, and vitamin E partially protected from oxidative damage, indicate that while all substances had antioxidant effects, only taurine showed morphological protection in surviving cells.
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