期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 15, 期 7, 页码 331-338出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2004.07.008
关键词
-
资金
- NIDDK NIH HHS [DK46943] Funding Source: Medline
Gonadotropin-releasing hormone (GnRH) binds to the pituitary GnRH receptor to activate signal transduction cascades that ultimately modulate gonadotropin biosynthesis. Comprehensive studies of the GnRH-activated gene program in the LbetaT2. gonadotrope cell line have greatly increased our knowledge of the number of early and intermediate gene transcripts that are modulated by GnRH. Among the classes of gene induced are several whose protein products provide feedback to various levels of signaling pathways, suggesting that gene induction forms an integral component of signal transduction and contributes to longer-timescale feedback and feedforward loops. High-throughput quantitative genomic studies, mathematical modeling and biochemical studies are beginning to delineate the organization and function of the signal-decoding and logic circuit modules of the gonadotrope's signal transduction network.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据