Genomics view of gonadotrope signaling circuits

Gonadotropin-releasing hormone (GnRH) binds to the pituitary GnRH receptor to activate signal transduction cascades that ultimately modulate gonadotropin biosynthesis. Comprehensive studies of the GnRH-activated gene program in the LbetaT2. gonadotrope cell line have greatly increased our knowledge of the number of early and intermediate gene transcripts that are modulated by GnRH. Among the classes of gene induced are several whose protein products provide feedback to various levels of signaling pathways, suggesting that gene induction forms an integral component of signal transduction and contributes to longer-timescale feedback and feedforward loops. High-throughput quantitative genomic studies, mathematical modeling and biochemical studies are beginning to delineate the organization and function of the signal-decoding and logic circuit modules of the gonadotrope's signal transduction network.