期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 24, 期 3, 页码 226-233出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2004.02.028
关键词
MecA; penicillin-binding protein; PBP2a; ILSMR; MRSA
We found that some flavonoids had a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA), but that at sub-MIC concentrations they greatly increased the susceptibility of these strains to beta-lactam antibiotics. Flavone showed diverse synergistic effects on the susceptibility of MRSA to beta-lactam antibiotics. The variation of the synergistic effects of the flavones to increase the susceptibility of strains of MRSA to beta-lactam antibiotics coincided with their varying effects on growth-inhibition of these strains. Based on these findings, we have proposed a model for the mechanisms of high resistance of MRSA to beta-lactams and the massive reduction in the beta-lactams MIC caused by flavones. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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