期刊
CELL COMMUNICATION AND ADHESION
卷 11, 期 5-6, 页码 137-153出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15419060500242836
关键词
transdifferentiation; signal transduction; extracellular matrix; stem cells
资金
- NIBIB NIH HHS [5R01EB002197-02] Funding Source: Medline
Adhesion to the extracellular matrix (ECM) proteins collagen I and vitronectin is sufficient to drive human mesenchymal stem cells (hMSCs) into an osteogenic differentiation pathway, but the mechanisms underlying this stimulation are not well understood. We found that addition of beta(1) and alpha(v)beta(3) integrin blocking antibodies inhibited ECM-induced ERK activation, while addition of the MEK inhibitor PD98059 blocked ERK activation, serine phosphorylation of the osteogenic transcription factor runx2/cbfa-1, osteogenic gene expression, and calcium deposition. These results suggest that ERK plays an important role in driving the ECM-induced osteogenic differentiation of hMSC.
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