4.7 Article

SRI-286, a thiosemicarbazole, in combination with mefloquine and moxifloxacin for treatment of murine Mycobacterium avium complex disease

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 48, 期 9, 页码 3556-3558

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AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.9.3556-3558.2004

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  1. NIAID NIH HHS [N01-AI25104] Funding Source: Medline

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Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone.

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