期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 46, 期 3, 页码 234-244出版社
WILEY
DOI: 10.1002/ajim.20049
关键词
jet fuel exposure; JP-8; biomarker; urine; naphthalene metabolism; 1-naphthol; 2-naphthol
资金
- NIEHS NIH HHS [T32ES07018, P42ES05948, P30ES10126] Funding Source: Medline
Background Jet propulsion fuel-8 (JP-8) is one of the largest sources of chemical exposures among Air Force personnel. Urinary naphthols have been suggested as useful biomarkers of exposure to JP-8. Methods Multivariate linear regression models were applied to evaluate the effects of environmental and work-related factors upon production of urinary naphthols among 323 Air Force personnel. Results Naphthalene exposure, smoking status, and their interaction, plus self-reported skin irritation explained about two-thirds of the variation in naphthol levels. The exposure-smoking interaction was consistent with induction by smoking of one or more steps in the metabolism of naphthalene and naphthalene-1,2-oxide (NapO). A supralinear dose-response relationship was observed between urinary naphthols and naphthalene exposure. Conclusions Urinary naphthols were associated with specific sources of exposure to JP-8, arising from both inhalation and dermal contact. Smokers and nonsmokers metabolized naphthalene at different rates, consistent with induction of at least two metabolic pathways by smoking. (C) 2004 Wiley-Liss, Inc.
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