期刊
CELL CYCLE
卷 3, 期 9, 页码 1133-1137出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.3.9.1145
关键词
c-Myc; Ras; ERK; GSK-3 beta; Pin1; PP2A; Threonine 58; Serine 62; stability
类别
资金
- NCI NIH HHS [R01-CA-100855, K01-CA-86957] Funding Source: Medline
The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.
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