期刊
IMMUNITY
卷 21, 期 3, 页码 315-329出版社
CELL PRESS
DOI: 10.1016/j.immuni.2004.08.006
关键词
-
类别
资金
- NHLBI NIH HHS [HL62524, HL56949, HL54936] Funding Source: Medline
- NIAID NIH HHS [AI061663] Funding Source: Medline
- NIAMS NIH HHS [AR042689] Funding Source: Medline
Recent advances in photonics, particularly multi-photon microscopy (MPM) and new molecular and genetic tools are empowering immunologists to answer long-standing unresolved questions in living animals. Using intravital microscopy (IVM) investigators are dissecting the cellular and molecular underpinnings controlling immune cell motility and interactions in tissues. Recent IVM work showed that T cell responses to antigen in lymph nodes are different from those observed in vitro and appear dictated by factors uniquely relevant to intact organs. Other IVM models, particularly in the bone marrow, reveal how different anatomic contexts regulate leukocyte development, immunity, and inflammation. This article will discuss the current state of the field and outline how IVM can generate new discoveries and serve as a reality check for areas of research that were formerly the exclusive domain of in vitro experimentation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据