期刊
AMERICAN JOURNAL OF HEMATOLOGY
卷 77, 期 1, 页码 72-76出版社
WILEY
DOI: 10.1002/ajh.20147
关键词
posterior leukoencephalopathy; hypertensive encephalopathy; eclampsia; cyclosporine encephalopathy; cytotoxic chemotherapy
类别
Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon but distinctive clinicoradiological entity comprising of headache, seizures, visual disturbance, and altered mental function, in association with posterior cerebral white matter edema. With appropriate management, RPLS is reversible in the majority of cases. Previous reported associations of RPLS include hypertension, eclampsia, renal failure, and use of immunosuppressive drugs; reports in the adult hematology setting are rare. We report two cases of adults undergoing treatment for hematological malignancies who developed RPLS, and we emphasize the importance of early recognition and institution of appropriate management in reducing the risk of development of permanent neurological disability. (C) 2004 Wiley-Liss, Inc.
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