期刊
BIOMEDICAL MICRODEVICES
卷 6, 期 3, 页码 177-182出版社
SPRINGER
DOI: 10.1023/B:BMMD.0000042046.07678.2e
关键词
microneedle; insertion force; vibratory actuation; drug delivery
The effect of vibratory actuation on microneedle insertion force was investigated. Hollow micro hypodermic injection needles were fabricated by a two-wafer polysilicon micromolding process. A vibratory actuator operating in the kHz range was coupled with the hypodermic microneedles. The force to insert microneedles into excized animal tissue was measured with a load cell. Results showed a greater than 70% reduction in microneedle insertion force by using vibratory actuation. The application of vibratory actuation provides a promising method to precisely control the microneedle insertion forces to overcome microneedle structural material limitations, minimize insertion pain, and enhance the efficiency of drug delivery.
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