期刊
PHYSICAL REVIEW LETTERS
卷 93, 期 10, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.93.108108
关键词
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Recent experiments indicate that double-stranded DNA molecules of approximately 100 base pairs in length have a probability of cyclization which is up to 10(5) times larger than that expected based on the known bending modulus of the double-helix. We argue that for short molecules, the formation of a few base pairs of single-stranded DNA can provide a flexible hinge that facilitates loop formation. A detailed calculation shows that this mechanism explains the experimental data.
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