期刊
BRAIN RESEARCH
卷 1019, 期 1-2, 页码 259-264出版社
ELSEVIER
DOI: 10.1016/j.brainres.2004.05.019
关键词
central nervous system; chronic mild stress; depression; immunohistochemistry; rat; reward
Chronic mild stress (CMS), an animal model of depression associated with anhedonia, was used to examine nucleus accumbens (NAc) activation associated with a rewarding stimulus. Following 4 weeks of CMS in rats, NAc Fos-immunoreactivity was measured after ingestion of a fixed volume of sucrose. Fewer Fos-positive neurons were observed in the NAc in CMS versus control rats. These findings have implications for the mechanisms underlying reduced responding to pleasurable stimuli associated with depression. (C) 2004 Elsevier B.V. All rights reserved.
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