期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 279, 期 36, 页码 37271-37281出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M403413200
关键词
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资金
- NHLBI NIH HHS [HL59949] Funding Source: Medline
The activity of specific inwardly rectifying potassium (Kir) channels is regulated by any of a number of different modulators, such as protein kinase C, G(q)-coupled receptor stimulation, pH, intracellular Mg2+ or the betagamma-subunits of G proteins. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an essential factor for maintenance of the activity of all Kir channels. Here, we demonstrate that the strength of channel-PIP2 interactions determines the sensitivity of Kir channels to regulation by the various modulators. Furthermore, our results suggest that differences among Kir channels in their specific regulation by a given modulator may reflect differences in their apparent affinity of interactions with PIP2.
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