期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 808, 期 2, 页码 141-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2004.04.030
关键词
doxorubicin; anthracyclines
资金
- NCI NIH HHS [R01 CA107570, R01 CA107570-01] Funding Source: Medline
- NCRR NIH HHS [S10 RR023650, S10 RR021221, S10 RR014592-01, S10 RR023650-01, S10RR14573, S10 RR021221-01] Funding Source: Medline
The anthracycline Doxorubicin (DXR) is used widely for the treatment of human malignancies, and drug delivery technologies are under investigation to enhance antitumor selectivity and effectiveness. A liquid chromatography-tandem mass spectroscopy (LC-MS/MS) method was developed to identify and quantify DXR and key metabolites in small-volume biological samples. The assay was linear over the therapeutically relevant concentration range (0.125-10,000 nM); in brain tissue, the lower limit of quantification was 0.247 nM and the sensitivity was 1.4 pg. The ability to quantify DXR and detect metabolite formation may provide insight into the toxicity and bioavailability of drug incorporated into carriers such as liposomes. OF (C) 2004 Elsevier B.V. All rights reserved.
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