期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 37, 页码 13472-13477出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0405568101
关键词
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资金
- NHGRI NIH HHS [R01 HG002338, R01 HG 02338] Funding Source: Medline
Broad-spectrum analysis of DNA and RNA samples is of increasing importance in the growing field of biotechnology. We show that nanopore measurements may be used to assess the purity, phosphorylation state, and chemical integrity of nucleic acid preparations. In contrast with gel electrophoresis and mass spectrometry, an unprecedented dynamic range of DNA sizes and concentrations can be evaluated in a single data acquisition process that spans minutes. Because the molecule information is quantized and digitally recorded with single-molecule resolution, the sensitivity of the system can be adjusted in real time to. detect trace amounts of a particular DNA species.
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