期刊
GENES & DEVELOPMENT
卷 18, 期 18, 页码 2195-2224出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1228704
关键词
NF-kappa B; I-kappa B; signal transduction; transcription factors; protein-serine-threonine
资金
- NIAID NIH HHS [R37-AI33443, AI59440] Funding Source: Medline
- NIGMS NIH HHS [GM07205] Funding Source: Medline
The transcription factor NF-kappaB has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-kappaB, although there are nuances in this important signaling pathway that still remain to be understood. The challenge now is to reconcile the regulatory complexity in this pathway with the complexity of responses in which NF-kappaB family members play important roles. In this review, we provide an overview of established NF-kappaB signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-kappaB transcriptional activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据