Podophyllotoxin:: distribution, sources, applications and new cytotoxic derivatives

Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines. Chemical transformations performed on these compounds have yielded derivatives more potent and more selective that the parent compound. Most of the compounds maintained their cytotoxicity at the muM level. Distribution, biosynthesis, production, biotechnology, applications and synthesis have also been reviewed. (C) 2004 Elsevier Ltd. All rights reserved.