期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 37, 期 6, 页码 768-784出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2004.06.008
关键词
matrix metalloprotemases; hydrogen peroxide; superoxide dismutase; cancer; reactive oxygen species; free radicals
资金
- NIAID NIH HHS [AI49822] Funding Source: Medline
Reactive oxygen species (ROS) are constantly generated in aerobic organisms during normal metabolism and in response to both internal and external stimuli. Imbalances in the production and removal of ROS have been hypothesized to play a causative role in numerous disease pathologies such as cancer, ischemia/reperfusion injury, and degenerative diseases such as photoaging, atherosclerosis, arthritis, and neurodegeneration. A feature often associated with these diseases is a malfunctioning of the connective tissue remodeling process due to increased activity of extracellular matrix-degrading metalloproteinases (MMPs). This review summarizes the evidence that implicates ROS as key regulators of MMP production and the importance of these interactions in disease pathologies. (C) 2004 Elsevier Inc. All rights reserved.
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