期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 56, 期 11, 页码 1537-1563出版社
ELSEVIER
DOI: 10.1016/j.addr.2003.10.047
关键词
targeted drug delivery; peptide assemblies; block-co-polymer micelles; bioconjugation
资金
- NHLBI NIH HHS [HL62427] Funding Source: Medline
Nature has evolved the ability to assemble a variety of molecules into functional architectures that can specifically bind cellular ligands. Mimicking this strategy requires the design of a set of multifaceted molecules, where elements that direct assembly were conjugated to biologically specific components. The development of functional molecular building-blocks that assemble to form compartments for therapeutics addresses the desire to have controllable morphologies that interact with biological interfaces at nanometer length scales. The practical application of such 'bottom-up' assemblies requires the ability to predict the type of aggregated structure and to synthesize molecules in a highly controlled fashion. This bottom-up approach results in a molecular platform that mimics biological systems with potential for encapsulating and delivering drug molecules. (C) 2004 Elsevier B.V. All rights reserved.
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