期刊
BEHAVIOURAL BRAIN RESEARCH
卷 154, 期 1, 页码 1-17出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2004.01.012
关键词
Down syndrome; Ts65Dn mice; aneuploidy; trisomy 21; trisomy 16; mouse model; Morris water maze
资金
- NCI NIH HHS [P30 CA034196] Funding Source: Medline
- NICHD NIH HHS [HD37113, HD24605, HD37424] Funding Source: Medline
The Ts65Dn mouse is the most studied and genetically the most complete animal model of Down syndrome (DS) available. These mice display many DS-like features, including performance deficits in different behavioral tasks, motor dysfunction, and age-dependent loss of cholinergic markers in the basal forebrain. At present, the only robust data demonstrating a behavioral deficit potentially associated with learning and memory in Ts65Dn mice less than 6 months old have come from studies that used some variation of the Morris water maze task. However, the specific features of the water maze deficits seen in these animals are still poorly defined. This study is an initial attempt to bridge this knowledge gap. We investigated three major factors potentially influencing the performance of Ts65Dn mice in the water maze: (1) order in which the test is executed; (2) age of the animals; and (3) levels of aversiveness associated with the test. Measurements of plasma corticosterone levels end core body temperature after swimming were also carried out in additional subsets of mice. Overall, we found that the behavioral phenotype of Ts65Dn mice was milder than previously described in the literature. Additionally, Ts65Dn mice were significantly more responsive to potential stressors and more prone to swim-induced hypothermia than euploid control animals. More studies are needed to tease out further the potential effects of confounding factors on the performance of Ts65Dn mice. (C) 2004 Elsevier B.V. All rights reserved.
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