期刊
FEBS LETTERS
卷 575, 期 1-3, 页码 23-29出版社
WILEY
DOI: 10.1016/j.febslet.2004.07.089
关键词
mitotic checkpoint protein; WD repeat; transcriptional repression; histone deacetylase; cell cycle arrest
WD repeats are implicated in protein-protein interactions and regulate a wide variety of cellular functions, including chromatin remodeling and transcription. The WD repeats of the Bub3 and Cdc20 kinetochore proteins are important for the physical interactions of these proteins with Mad2 and BubR1 to yield a kinetochore protein complex capable of delaying anaphase by inhibiting ubiquitin ligation via the anaphase-promoting complex/cyclosome. Here, we show that Bub3 and Cdc20 form a complex with histone deacetylases; this interaction appears to confer transcriptional repressor activity in a heterologous DNA-binding context. In addition, inhibition of Bub3 and Cdc20 expression significantly impairs interphase cell cycle. These results indicate that Bub3 and Cdc20 play additional roles in the integration of cell cycle arrest as transcriptional repressors. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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