期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 108, 期 39, 页码 15311-15320出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp048935f
关键词
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Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system provide natural measures for the propagation of the input signal down the cascade and for the characterization of the final outcome. The most efficient design of a cascade for generating sharp signals is obtained by choosing all the off rates equal and a universal finite optimal length.
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