期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 138, 期 1-2, 页码 27-37出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2004.03.005
关键词
electrical stimulation; dissociated-culture; multi-electrode array; MEA; stimulation parameters
资金
- NIBIB NIH HHS [EB000786] Funding Source: Medline
- NINDS NIH HHS [NS38628, R01 NS038628-04, NS044134] Funding Source: Medline
Electrical stimulation through multi-electrode arrays is used to evoke activity in dissociated cultures of cortical neurons. We study the efficacies of a variety of pulse shapes under voltage control as well as current control, and determine useful parameter ranges that optimize efficacy while preventing damage through electrochemistry. For any pulse shape, stimulation is found to be mediated by negative currents. We find that positive-then-negative biphasic voltage-controlled pulses are more effective than any of the other pulse shapes tested, when compared at the same peak voltage. These results suggest that voltage-control, with its inherent control over limiting electrochemistry, may be advantageous in a wide variety of stimulation scenarios, possibly extending to in-vivo experiments. (C) 2004 Elsevier B.V. All rights reserved.
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