期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 23, 期 8-9, 页码 1135-1139出版社
TAYLOR & FRANCIS INC
DOI: 10.1081/NCN-200027391
关键词
N1-methyl-2-pyridone-5-carboxamide (Me2Py); uraemia; pyridine nucleotide; HPLC; LC/MS
We have investigated an unusual nucleotide that accumulates, with precursors, in the erythrocytes of patients in uraemia. This nucleotide is related chemically to the NAD breakdown product, N1-methyl-2-pyridone-5-carboxamide (Me2Py), found in high concentrations in the plasma of uraemic patients. Both Me2Py and the nucleotide accumulate to high concentrations in the blood during uraemia: our investigations of samples from renal out-patients have provided information on a plausible link between the two compounds.
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