期刊
NEUROBIOLOGY OF AGING
卷 25, 期 9, 页码 1197-1203出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2003.12.007
关键词
hippocampal formation; temporal lobe; imaging; aging; memory
资金
- NIA NIH HHS [R01 AG17917, P01 AG09466, T32 AG00269, P30 AG10161] Funding Source: Medline
With high-resolution quantitative magnetic resonance imaging (MRI) techniques, it is possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD). In the present study, 27 patients diagnosed with mild cognitive impairment (MCI) received a high-resolution MRI scan at baseline and were followed with yearly clinical evaluations. Ten of the 27 patients converted to AD during a 36-month period following the baseline clinical evaluation. Hippocampal and entorhinal cortex volumes derived from the baseline scan were compared to determine which of these two regions, known to be pathologically involved very early in the course of AD, could best differentiate MCI converters from non-converters. Although both entorhinal and hippocampal volumes were found to be independent predictors of the likelihood of conversion to AD, it was the right hemisphere entorhinal volume that best predicted conversion with a concordance rate of 93.5%. (C) 2004 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据