期刊
CURRENT NEUROVASCULAR RESEARCH
卷 1, 期 4, 页码 355-371出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567202043362018
关键词
neuronal apoptosis; apoptosis and neurodegeneration; mitochondrial apoptotic signaling; oxidative stress and apoptosis; apoptosis and cerebrovascular injury; cerebral ischemia/reperfusion
资金
- NIDDK NIH HHS [DK 43785, R01 DK044510, R01 DK044510-11, DK 44510] Funding Source: Medline
Apoptosis is an important process in the development of the nervous system. Typically, similar to50% of the neurons apoptose during neurogenesis before the nervous system matures. However, recent paradigms implicate premature apoptosis and/or aberrations in the fine control of neuronal apoptosis in the pathogenesis of a variety of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, stroke, brain trauma, spinal cord injury, and diabetic neuropathy. This review will focus on the current concepts salient to understanding the apoptosis death program, the mediators and control of cellular apoptosis, and the relationship between aberrant apoptosis and genesis of neurodegenerative disorders. The discussion will also highlight current advances in methodology, such as utilization of neuronal cell lines and mutant animal models, in investigations of neuronal apoptotic death. The knowledge of apoptosis mechanisms could underpin the basis for development of novel therapeutic strategies and treatment modalities that are directed at control of the neuronal apoptotic death program.
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