期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 46, 期 4, 页码 396-399出版社
WILEY-LISS
DOI: 10.1002/ajim.20088
关键词
farmers; asthma; atopy; endotoxins; fungal spores
Background In a previous study inverse associations between asthma and exposure to fungal spores and endotoxins in atopic farmers and positive associations with the same factors in non-atopic farmers were documented. No external reference population had been included. We, therefore, compared this farming population with the general population from an adjacent region. Methods Random samples of a farming (n = 2,106) and a rural (n = 351) and urban (n = 727) general population were selected. Atopy was assessed by serum IgE and asthma by questionnaires. Results The asthma prevalence was 4.0% among farmers, 5.7% in the rural, and 7.6% in the urban population. Atopy was similar (9-10%). Most asthmatics were not atopic, 67-75%. Farmers had asthma less often than the general population OR 0.52 (95% CI 0.36-0.75); both atopic (OR 0.33 (95% CI 0.15-0.69)) and non-atopic asthma (OR 0.60 (95% CI 0.39-0.93)). Conclusion This may indicate a protective effect of the farm environment on asthma but a healthy worker effect may also play a role. (C) 2004 Wiley-Liss, Inc.
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