期刊
INFECTION AND IMMUNITY
卷 72, 期 10, 页码 6160-6163出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.10.6160-6163.2004
关键词
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In this study, we investigated the ability of Fusobacterium nucleatum subsp. nucleatum to increase its tissue-invasive potential by acquiring cell-associated human matrix metalloproteinase 9 (MMP-9) activity. Binding of pro-MMP-9 to fusobacteria was demonstrated by enzyme-linked immunosorbent assay. Zymography and a colorimetric assay showed that bound pro-MMP-9 can be converted into a proteolytically active form. The potential contribution of this acquired host activity in tissue invasion was demonstrated using a reconstituted basement membrane (Matrigel).
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