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AMERICAN JOURNAL OF PSYCHIATRY
卷 161, 期 10, 页码 1916-1918出版社
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.161.10.1916
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Objective: Bulimia nervosa has been associated with alterations in central serotonergic (5-HT) function. This study investigated iodine-labeled 4-amino-N-[1-[3-(4-fluorophenoxy) propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide ((123)l-5-l-R91150) binding to the 5-HT2A receptor in the brain by usingsingle photon emission computed tomography in acutely ill bulimia nervosa patients. Method: Cortical (123)l-5-l-R91150 binding in 10 normal-weight patients with bulimia nervosa, purging type, was compared with that of 11 healthy volunteers. Results: The 5-HT2A binding index of the bulimia nervosa patients, with and without correction for age, was not significantly different from that of the comparison group. Conclusions: As a group, acutely ill bulimia nervosa patients cannot be discriminated from healthy subjects on the basis of cortical (123)l-5-l-R91150 binding to the 5-HT2A receptor.
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