期刊
APPLIED PHYSICS LETTERS
卷 103, 期 23, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4836315
关键词
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资金
- NSF
- University of Michigan MCube program
Pulsed ultrasonic cavitation is a promising modality for non-contact targeted therapy, enabling mechanical ablation of the tissue. We demonstrate a spatio-temporal superposition approach of two ultrasound pulses (high and low frequencies) producing a tight cavitation zone of 100 mu m in water, which is an-order-of-magnitudes smaller than those obtained by the existing high-amplitude transducers. Particularly, laser-generated focused ultrasound (LGFU) was employed for the high-frequency operation (15 MHz). As demonstrated, LGFU plays a primary role to define the cavitation zone. The generation rate of cavitation bubbles could be dramatically increased up to 4.1% (cf. 0.06% without the superposition) with moderated threshold requirement. (C) 2013 AIP Publishing LLC.
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