期刊
PROTEIN AND PEPTIDE LETTERS
卷 11, 期 5, 页码 443-450出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866043406562
关键词
HB-EGF; ADAM12; metalloproteinase; ectodomain shedding; GPCR; EGFR transactivation; wound healing; cardiac hypertrophy
Heparin-binding EGF-like growth factor (HB-EGF) exists as a membrane-anchored form (profHB-EGF) and as its soluble cleaved product (sHB-EGF). The conversion (ectodomain shedding) of proHB-EGF to sHB-EGF is tightly regulated by specific metalloproteinases. Ectodomain shedding plays a central role in GPCR-mediated EGFR transactivation. Antagonizing metalloproteinases can inhibit EGFR transactivation and might be of therapeutic value, for example in cardiac hypertrophy, skin remodeling and tumor growth.
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