期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 19, 期 10, 页码 1619-1627出版社
WILEY-BLACKWELL
DOI: 10.1359/JBMR.040704
关键词
osteoporosis; single nucleotide polymorphism; linkage; association; LRP5 gene
Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.
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