期刊
FEMS MICROBIOLOGY LETTERS
卷 239, 期 1, 页码 157-161出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2004.08.033
关键词
nisin; resistance; bactoprenyl-phosphate; Lipid II
类别
Lipid II is essential for nisin-mediated pore formation at nano-molar concentrations. We tested whether nisin resistance could result from different Lipid II levels, by comparing the maximal Lipid II pool in Micrococcus flavus (sensitive) and Listeria monocytogenes (relatively insensitive) and their nisin-resistant variants, with a newly developed method. No correlation was observed between the maximal Lipid II pool and nisin sensitivity, as was further corroborated by using spheroplasts of nisin-resistant and wild-type strains of M. flavus, which were equally sensitive to nisin. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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