Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana

Nine monotetrahydrofuranic Annonaceous acetogenins, montalicins A - E (1 - 5), cis-annoreticuin (6), montalicins F (7), 1 (8), and J (9), along with eight known acetogenins 10-17, were isolated from the seeds of Annona montana by a high performance liquid chromatographic (HPLC) method. The structures of all new isolates were elucidated and characterized by spectro-scopic and chemical methods. These monotetrahydrofuranic Annonaceous acetogenins showed selectively potent cytotoxicity against two human cancer cell lines, 1A9 and Hep G2.