期刊
APPLIED PHYSICS LETTERS
卷 102, 期 12, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4798495
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- University of Toronto through a Connaught Innovation Award
- Canada Research Chairs Program
This study investigates whether mechanical differences exist between benign and malignant urothelial cells in voided urine. The Young's modulus of individual cells was measured using the micropipette aspiration technique. Malignant urothelial cells showed significantly lower Young's modulus values compared to benign urothelial cells. The results indicate that Young's modulus as a biomechanical marker could possibly provide additional information to conventional urinary cytology. We hope that these preliminary results could evoke attention to mechanical characterization of urine cells and spark interest in the development of biomechanical approaches to enhance non-invasive urothelial carcinoma detection. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4798495]
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