期刊
ELECTROPHORESIS
卷 25, 期 20, 页码 3441-3449出版社
WILEY
DOI: 10.1002/elps.200406067
关键词
capillary electrophoresis; dynamic coated capillaries; mass spectrometry; water samples
We describe an analytical method involving solid-phase extraction (SPE) and capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) for determining some pharmaceutical compounds - naproxen, clofibric acid and bezafibrate - in real water samples. The electrospray parameters were optimized to maximize sensitivity. When a mixed aqueous-organic solvent and CZE-ESI-MS were used to analyze these drugs in water samples, the capillary was coated with hexadimethrin bromide (HDB) to permanently reverse the EOF. The method was developed from offline SPE-CZE-IVIS and was validated with surface water. The detection limits were 100 mug - L-1 for all analytes. The method was applied to analyze water samples from the influent and effluent of a sewage treatment plant. A liquid-liquid extraction step was required before SPE, and the compounds studied were found, some of them between detection and quantification limits.
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