期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 97, 期 4, 页码 1343-1348出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01101.2003
关键词
transcranial Doppler ultrasound; middle cerebral artery velocity; cortical blood flow
Nocturnal hypoxia is a major pathological factor associated with cardiorespiratory disease. During wakefulness, a decrease in arterial O-2 tension results in a decrease in cerebral vascular tone and a consequent increase in cerebral blood flow; however, the cerebral vascular response to hypoxia during sleep is unknown, In the present study, we determined the cerebral vascular reactivity to isocapnic hypoxia during wakefulness and during stage 3/4 non-rapid eye movement (NREM) sleep. In 13 healthy individuals, left middle cerebral artery velocity (MCAV) was measured with the use of transcranial Doppler ultrasound as an index of cerebral blood flow. During wakefulness, in response to isocapnic hypoxia (arterial O-2 saturation -10%), the mean (+/-SE) MCAV increased by 12.9+/-2.2% (P<0.001); during NREM sleep, isocapnic hypoxia was associated with a -7.4 +/- 1.6% reduction in MCAV (P<0.001). Mean arterial blood pressure was unaffected by isocapnic hypoxia (P>0.05); R-R interval decreased similarly in response to isocapnic hypoxia during wakefulness (-21.9+/-10.4%; P<0.001) and sleep (-20.5 +/- 8.5%; P<0.001). The failure of the cerebral vasculature to react to hypoxia during sleep Suggests a major state-dependent vulnerability associated with the control of the cerebral circulation and may contribute to the pathophysiologies of stroke and sleep apnea.
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