期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 15, 期 8, 页码 362-369出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2004.07.009
关键词
-
资金
- NIDDK NIH HHS [DK 12829, DK 52989, DK 17047, DK 64857-01] Funding Source: Medline
- NINDS NIH HHS [NS 32273] Funding Source: Medline
Despite an alarming increase in the burden of obesity worldwide, body adiposity seems to be a regulated physiological variable. Regulation of adiposity occurs through a classical endocrine feedback loop, in which the pancreatic beta-cell-derived hormone insulin and the adipocyte-derived hormone leptin signal the status of body energy stores to the hypothalamus. Recent advances in our understanding of the signal transduction mechanisms used by insulin and leptin in the hypothalamus to modulate neuronal firing suggest that intracellular cross-talk occurs at several levels and is a potentially important determinant of regulated body weight. These pathways are thus an attractive target for pharmacological intervention in the treatment of obesity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据