期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 342, 期 5, 页码 1415-1421出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2004.08.003
关键词
quasispecies; VSV; experimental evolution; fitness; positive selection
资金
- NIAID NIH HHS [R01-AI45686] Funding Source: Medline
Prevailing evolutionary forces are typically deduced from the pattern of differences in synonymous and non-synonymous mutations, under the assumption of neutrality in the absence of amino acid change. We determined the complete sequence of ten vesicular stomatitis virus populations evolving under positive selection. A significant number of the mutations occurred independently in two or more strains, a process known as parallel evolution, and a substantial fraction of the parallel mutations were silent. Parallel evolution was also identified in non-coding regions. These results indicate that silent mutations can significantly contribute to adaptation in RNA viruses, and relative frequencies of synonymous and non-synonymous substitutions may not be useful to resolve their evolutionary history. (C) 2004 Elsevier Ltd. All rights reserved.
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