期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 15, 期 5, 页码 529-540出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2004.05.009
关键词
development; edg receptor; long chain base; sphingolipid; sphingosine-1-phosphate
资金
- NCI NIH HHS [1R01CA77528] Funding Source: Medline
- NIGMS NIH HHS [1R01GM066954] Funding Source: Medline
Sphingosine-1-phosphate (S1P) is a signaling molecule that regulates critical events including mammalian cell proliferation, survival, migration and cell-cell interactions. Most of these signals are triggered by engagement of sphingosine-1-phosphate receptors of family. However, accumulating evidence derived from investigation of non-mammalian models that lack Edg receptors suggests that sphingosine-l-phosphate-like molecules can act through alternative mechanisms and thereby contribute to morphogenesis, development, reproduction and survival. This review provides an overview of sphingosine-1-phosphate metabolism, the isolation of genes in this pathway employing yeast genetics, the evidence for its influence on non-mammalian development, and the pertinence of these findings to human disease. (C) 2004 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据