期刊
BIOSTATISTICS
卷 5, 期 4, 页码 557-572出版社
OXFORD UNIV PRESS
DOI: 10.1093/biostatistics/kxh008
关键词
array CGH; binary segmentation; change-point; ROMA
资金
- NCI NIH HHS [CA73848, CA078544, CA45508] Funding Source: Medline
DNA sequence copy number is the number of copies of DNA at a region of a genome. Cancer progression often involves alterations in DNA copy number. Newly developed microarray technologies enable simultaneous measurement of copy number at thousands of sites in a genome. We have developed a modification of binary segmentation, which we call circular binary segmentation, to translate noisy intensity measurements into regions of equal copy number. The method is evaluated by simulation and is demonstrated on cell line data with known copy number alterations and on a breast cancer cell line data set.
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