期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 11, 期 10, 页码 1021-1022出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb835
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The origin licensing repressor geminin is a unique bifunctional protein providing a molecular link between cellular proliferation, differentiation and genomic stability. Here we report the first molecular structure of human geminin, determined by EM and image processing at a resolution of 17.5 Angstrom. The geminin molecule is a tetramer formed by two dimers with monomers interacting via coiled-coil domains. The unusual structural organization of geminin provides molecular insight into its bifunctional nature.
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