期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 46, 期 4, 页码 349-356出版社
WILEY
DOI: 10.1002/ajim.20000
关键词
livestock farming; asthma; allergies; dermatitis; Th2; hygiene hypothesis; epidemiology; cross-sectional study; endotoxins; farmer
Background Several studies reported protective effects of farming environments against atopic diseases. Therefore, we aimed to establish the relevant timing of exposure in early life. Methods A cross-sectional study was carried out in a rural town. Overall, 4,537 inhabitants aged 18-44 years were eligible. Of these, 3,112 (69%) responded to a postal questionnaire on atopic diseases, life-time exposure to farming environments, and potential confounders. Results Those with regular childhood exposure to animal buildings had a significantly reduced risk of nasal allergies. The greatest reduction in risk was seen for respondents starting regular visits to animal stables during the 1st year of life or between ages 3 and 5. Participants reporting start of exposure after age 5 remained at a lower risk for nasal allergies (0.70, 0.49-1.01). Conclusions The preventive effect of animal buildings' exposure against atopic respiratory diseases continues into adulthood. The magnitude of the effect appears to be age-dependent. (C) 2004 Wiley-Liss, Inc.
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