期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 52, 期 10, 页码 1639-1647出版社
WILEY
DOI: 10.1111/j.1532-5415.2004.52455.x
关键词
myocardial infarction; stroke; total mortality; cholesterol; lipids; older adults
资金
- NHLBI NIH HHS [N01-HC-85081, N01-HC-85083, HL43201, N01-HC-85082, N01-HC-85084, N01-HC-85080, N01-HC-85086, N01-HC-85079, N01-HC-85085] Funding Source: Medline
- NIA NIH HHS [AG09556] Funding Source: Medline
- CCR NIH HHS [RC-HL35129, RC-HL15103] Funding Source: Medline
Objectives: To assess the association between lipid levels and cardiovascular events in older adults. Design: A prospective population-based study. Setting: Four field centers in U.S. communities. Participants: A total of 5,201 adults aged 65 and older living in U.S. communities, plus a recruitment of 687 African Americans 3 years later. Measurements: Fasting lipid measures included low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol, and triglycerides. Results: At baseline, 1,954 men and 2,931 women were at risk for an incident myocardial infarction (MI) or stroke. During an average 7.5-year follow-up, 436 subjects had a coronary event, 332 had an ischemic stroke, 104 a hemorrhagic stroke, and 1,096 died. After adjustment, lipid measures were not major predictors of the outcomes of MI, ischemic stroke, hemorrhagic stroke, and total mortality. For total cholesterol and LDL-C, the associations with MI and ischemic stroke were only marginally significant. HDL-C was inversely associated with MI risk (hazard ratio=0.85 per standard deviation of 15.7 mg/dL, 95% confidence interval=0.76-0.96). For the outcome of ischemic stroke, high levels of HDL-C were associated with a decreased risk in men but not women. Lipid measures were generally only weakly associated with the risks of hemorrhagic stroke or total mortality. Conclusion: In this population-based study of older adults, most lipid measures were weakly associated with cardiovascular events. The association between low HDL-C and increased MI risk was nonetheless strong and consistent.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据